Pharmaceutics- I&II || practice day 3 || 50 mcq questions with answer || OSSSC || OSSC|| for Any private job AND GOVT. JOB
51.
All of the following statements concerning
chemical degradation are true except :
(a)As temperature increase, degradation
decreases
(b) Most drug degrades by a first order process
(c) Chemical degradation may produce a toxic
product
(d)Chemical degradation may affect the therapeutic activity of a drug.
52.
The pH of a buffer system can be calculated by :
(a) Noyes-Whitney equation
(b) Handerson Hasselbalch equation
(c)Mechaelis Menten equation
(d) Stokes equation
53.
The pH value is calculated mathematically
(a)Log of the OH- concentration
(b) Negative log of OH concentration
(c) Ratio of H+/O H- concentration
(d) Negative log of H* concentration
54.
Which of the following is highly responsible for chemical degradation :
(a) Oxidation
(b) Reduction
(c) Racemisation
(d) Hydrolysis
55.
Which f the following is correct for spans
(a) Produces w/o emulsions
(b)Hydrophilic in nature
(c)Have a HLB 3-10
(d) Artacel - 60
(e) All the above
56.
Myr 52 is
(a) Sodium oleate
(b) Polyoxy ethylene lauryl either
(c) Polyoxy ethylene moonostearate
(d) Polyoxy ethylene castor oil
57.
Dry gum method for emulsion preparation is also known as :
(a) English method
(b) Continental methodolsited
(c) Bottle method
(d) Nascent soap method
58.
Which of the following is wrong for commercial base and type of emulsion produced :
(a) Allercreme skin lotion-o/w402
(b) Cetapnyl-O/w
(c) Dermovan - o/w
(d) Eucerin - 0/w
59.
Choose the correct one for commercial base and type of emulsion produced
(a) HEB base -o/w
(b) Lubriderm-w/o
(c) Neo base - w/o
(d) Velvation - w/o
60.
Lanolin is
(a) Anhydrous woolfat
(b) Hydrous woolfat
(c) Lantrol
(d) Atlas G - 1794
61.
Which of the following is/are suppositry bases :
(a) Cocoa butter
(b) Cotmar
(c) Wecobee R
(d) all the above
62.
Cocoa butter exhibits all of the following properties except :
(a) It is soluble in water 30l svijngalt
(b) It is a polymorph OLH TO
(c) It melts at a temperature 33° and 35°
(d) It is mixture of glycerids
63.
Levigation is used in the extemporaneus
preparation of a suspension for:
(a) Reduce particle size nice nazaS(3)
(b) Reduce zeta potential o liot agi I stoid/
(c) Reduce particle size
(d) Reduce viscosity
64.
The particle size of the dispersed solid as a suspension is greater than
(a) 0.1 um
(b) 0.5 um
(c) 0.2 um
(d) 0.4 um
65.
The shells of soft gelatin capsules may be made
elastic or plastic like by the addition of :
(b) Povidone
(a) Sorbitol
(d) Lactose
(c) PEG
66 .
Non ionic surfactant used as synthetic emulsife- is :
(a)Tragacanth
(b) Spans
(c) Tweens
(d) Sodium lauryl sulphate
67.
_____is used in enteric coated tablets :
(a) HPMC
(6) CMC
(c)CAP
(d) All the above
68. According to the USP standard, the fine, particles should pass through
(a) No. 20 sieve
(b) No. 40 sieve
(c) No. 80 sieve
(d) No. 120 sieve
69.
Sulphur dioxide is used in gelatin preparation:
(a) as colouring agent
(b) to prevent decomposition
(c) to reduce the bitterness
(d) All the above
70.
Cab-o-sil is used as
(a) Anti adherent
(c) Disintegrant
(b) Lubricant
(d) Glidant
71.
'rem' indicates :
(a) Radiation per milli seconds
(b) Radiation per minute sil
(c) Roentgen exposure per minute
m (d) Roentagen-equivalent-man
72.
Cooling of medicaments prior to administration is to increase :
(a). Absorption
(c) Stability
(b) Palatability
73.
Medihaler is related to
(d) Gastric mtility
(a) Sustained releasee
(b) Parenterals
(c) Packaging
(d) Aerosols
74.
Plastics are normally sterilised with :
(a) Steam under pressure
(b) Steam under vacuum
(c) Ethylene oxide
(d) Dry heat sterilisation
75.
Pharmaceutical importance of Simethicone:
(a) Antiadherent
(c)Glidant
(b) Antifoaming
(d) Emulsifying agent
Which is not a method of splitting emulsions ?
(a) Centrifuging
(b) Filtering
(c) Addition f electrolytes
(d)Heat
77.
What happens if distribution of drug is slower than the processes of metabolism and exception
(a) High blood levels of drug
(b) Failure to attain diffusion equilibrium
(c)Low blood levels of drug
(d) Synergism
78.
Contact angle is related to :
(a) Disintegration of tablet 5r riA
(b)Moisture contact of tablet on
(c)Coefficient of friction of powder
(d) Spreadability or ointment
79.
Particle size reduction will not enhance the absorption of :
(a) Hydrphobic compounds
(b) Hydrophilic compounds a site9
(c)Weak acids
(d)Weak bases
80.
The purpose of paraben in syrups is as :
(a) Solubiliser
(b) Preservative
(c) Buffer
(d) Tonicity builder
81.
pH is equivalent to pKa at
(a) Neutralisation point
(b) pH of 1
(c)pH of 7
(d) Half neutralisation point
82.
Agglomeration of particles in emulsion is called :
(a) Polymerisation
(b) Demerisation
(c) DichrmatisM
(d) Coalescence
83.
The label for ophthalmic boric acid solution should
contain :
(a) Dilute with equal volume of distilled water
(b)Dilute with equal volume of sterile distilled water ca
(c) Dilute with equal volume of sterile isotonic saline solution
(d) None of the above
84.
Which of the following statistical technique(s) is/ are useful for clinical trial :
(a) Latin square
(b) 'F' test
(c)"T' test
(d) All the above
85.
Spans and Tweens are :
(a) Highly polymerised mannuronic acid anhydrides
(b)Phospholipids
(c)Polyoxyalkene derivatines
(d) Glycosides
86.
Complexation may mdify
(a)Odor and taste
(b) Taste and solubility
(c)Chemical structure and solubility
(d) Stability and solubility Unbli
87.
The principal factors that make enteric coated
tablets unpredictable in drug therapy :
(a) Failure to release drug
(b) Varying thickness of the coating
(c) Prematere release of drug
(d) pH
88.
The storage condition for pharm. aerosols is
(a) below 100°F
(b) below 95°F
(c) 25°C or less
(d) below 120°F
89.
Amorphous forms of drugs are:
(a)Usually less soluble than crystal forms
(b)Usually more soluble than crystal forms.
(c) Practically insoluble
(d)
90.
Have same solubility as that of crystal forms is a :
(a)Suspending agent
(b) Surfactant
(c) Deflocculant
(d) Propellant
91.
"Povan' is a :Zom
(a) Surfactant
(b) Lubricant
(c) Derflocculant
(d) Cyanine dye
92.
The rate limiting step in the bioavailability of a
capsule is :
(a) Disintegration.
(b) Dissolution
(c) Physical stability (d) pH
93.
PABA used in sunserren may cause :
(a) Staining of skin
(b) Staining of cloths
(c) Irritation
(d) Skin damage
94.
Sink condition is related to :
(a) In vitro evaluation
(b) In vivo evaluation
(c) Stability testing
(d) All the above
95.
A substance used frequently to polish tablets is :
(a) Sodium chloridE
(b) Lactse
(c)Calcium chloride
(d) AIr dried talc
96.
An isotonic solution is ne which :
(a) has a freezing point less than that of plasma
(b) has same salt composition of plasma
(c)does not cause crenulation
(d) does not cause hemolysis
97.
Passive diffusion :
(a) means 90% of drugs get absrbed
(b) is usually slow
(c) requires no energy
(d) all the above
98.
Penicillamine is a :
(a)humectant
(b) surfactant
(c) chelating agent
(d) chelating agent
99.
In the suggested terminology to describe the organoleptie properties of pharmaceutical powders, the off white colour will have ____odour and ____Taste.
(a) Pungent and accdic respectively
(b)Sulfurs and bitter respectively
(c) Aromatic and cutense respectively
(d) Pungent and Bittwer respectively
100.
The pnesence of armatic amines, as an impurity in formulation may be :
(a)Carcinogenic
(b) Decrease the poteney
(c) Both
(d) None of the above
ANSWRE
